Diethyl Ether → HCID 58933821, compound

Participants

Reaction Steps

4-({[2-(2,4-Dimethoxy-benzylamino)-pyridine-4-carbonyl]-amino}-methyl)-piperidine-1-carboxylic acid benzyl ester (EXAMPLE 171) (124 mg) in dichloromethane (5 mL) was treated with trifluoroacetic acid (0.5 mL). After 30 min, the reaction mixture was partitioned between EtOAc and dilute sodium bicarbonate solution. The organic layer was washed with brine, dried and the solvent evaporated to give the crude product which was stirred with ether (3mL) and filtered to give the 4-{[(2-amino-pyridine-4-carbonyl)-amino]-methyl}-piperidine-1-carboxylic acid benzyl ester as a white solid.

Provenance & Evidence