HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Benzyl (piperidin-4-ylmethyl)carbamate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-N-Boc-4-(N-cbz-aminomethyl)piperidine | HCID 11792026 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Benzyl (piperidin-4-ylmethyl)carbamate hydrochloride | HCID 45072217 | — |
Reaction Steps
A mixture of 35 g of 4-(benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester and 50 mL of 4N HCl in dioxane was stirred at rt for 3 h, then diluted with 200 mL of ether and filtered. The piperidin-4-ylmethyl-carbamic acid benzyl ester hydrochloride salt was obtained as a white fluffy solid. The free base was obtained by partitioning the hydrochloride between 50 mL chloroform and 50 mL saturated aqueous Na2CO3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259157B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-f3afd1b4c0234bfa872347379dbdd1c9 |
| Source note | uspto-grants-2007_08 |