HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Amino-pyrimidine-5-carboxylic acid [1-(2-p-tolyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-((tert-Butoxycarbonyl)amino)pyrimidine-5-carboxylic acid | HCID 21471626 | — |
| Reactant | C-[1-(2-p-tolyl-ethanesulfonyl)-piperidin-4-yl]-methylamine | HCID 69418130 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Amino-pyrimidine-5-carboxylic acid [1-(2-p-tolyl-ethanesulfonyl)-piperidin-4-ylmethyl]-amide | HCID 58933427 | — |
Reaction Steps
The title compound was prepared from C-[1-(2-p-tolyl-ethanesulfonyl)-piperidin-4-yl]-methylamine and 2-tert-butoxycarbonylamino-pyrimidine-5-carboxylic acid, followed by treatment with 4N HCl in dioxane as described in EXAMPLE 192.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259157B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-8a7e80f6fe31414cb3a80dbbd5aeb8fa |
| Source note | uspto-grants-2007_08 |