HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 2-(2,2-Dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Bromopyruvic Acid | HCID 70684 | — |
| Reactant | 2-Amino-2-thioxoethyl 2,2-dimethylpropanoate | HCID 2782113 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(2,2-Dimethyl-propionyloxymethyl)-thiazole-4-carboxylic acid | HCID 11096820 | — |
Reaction Steps
To a solution of bromopyruvic acid (0.37 g, 2.22 mmol) and 2-(tert-butylcarbonyloxy)thioacetamide (0.41 g, 2.22 mmol) in ethanol (20 ml) was added 4 A molecular sieves (2 g). After stirring for 15 h, 20 mL of dichloromethane was added. The mixture was stirred 5 min and filtered to give the product as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259157B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-48dd6845f4d24862a7e1bae3c8ad8775 |
| Source note | uspto-grants-2007_08 |