反应详情

To a solution of 2-(methylthio)pyrimidine-4-carboxylic acid (1.88 g (11.1 mmol) in THf (200 mL) was added Oxone (20.4 g, 33.1 mmol) in water (50 mL). The suspension was stirred for 24 h, then evaporated to dryness. The resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc. The combined extracts were dried over anhydrous MgSO4, filtered and concentrated to give the sulfone as a white solid.

1. customevaporated to dryness
2. extractionThe resulting white paste was extracted 5× each 100 mL EtOAc and 5% MeOH in EtOAc
3. dry with materialThe combined extracts were dried over anhydrous MgSO4
4. filtrationfiltered
5. concentrationconcentrated