Ammonium Hydroxide → 2-Amino-thiazole-5-carboxylic acid ethyl ester

Participants

Reaction Conditions

Reaction Steps

To a mixture of B-ethoxyacrylic acid ethyl ester (2.0 g, 13.9 mmol) in 1:1 dioxane/water (15 mL) at −10°0 C. was added NBS (2.72 g, 15.3 mmol). Thiourea (1.06 g, 13.9 mmol) was added and the mixture was heated to 80° C. and stirred for 1.5 h. The reaction mixture was cooled to 0° C. and 5 mL of saturated ammonium hydroxide was added. A precipitate formed in 15 min. The solid was filtered, washed with water and dried under vacuum, yielding a light orange solid.

Provenance & Evidence