4-Aminomethyl-1-N-Cbz-piperidine → Benzyl 4-{[({2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-5-yl}carbonyl)amino]methyl}piperidine-1-carboxylate

HRID 854335Notes

Reaction equation

HRID 854335 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][C:11]([C:14]([OH:16])=O)=[CH:12][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:17][CH2:18][CH:19]1[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[O:26])[CH2:21][CH2:20]1>>[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][C:11]([C:14]([NH:17][CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25]([O:27][CH2:28][C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:26])[CH2:21][CH2:20]2)=[O:16])=[CH:12][N:13]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 219554994-Aminomethyl-1-N-Cbz-piperidineHCID 222714422-N-Boc-Amino-Thiazole-5-Carboxylic Acid

Product 1

HCID 58933836Benzyl 4-{[({2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-5-yl}carbonyl)amino]methyl}piperidine-1-carboxylate

Procedure

2-[(tert-Butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid was coupled to benzyl 4-(aminomethyl)piperidine-1-carboxylate according to the procedure for EXAMPLE 1.

Sources & evidence

ORD record
ord-6630a77f07de42ffb0a246ee82dd7090
Source dataset
uspto-grants-2007_08
Patent number
US07259157B2

Reaction notes

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