Diethyl Ether → HCID 9868218, compound

Participants

Reaction Steps

A solution of 2 g of 4-(3-chloro-4-methoxybenzylamino)-2-chloromethyl-5,6,7,8 tetrahydrobenzothieno[2,3-d]pyrimidine in 10 ml of DMF is treated with 5 ml of 3-aminopropanol and heated at 80° for one hour. It is then diluted with water and extracted with ethyl acetate. The crystalline product obtained after customary work-up is dissolved in alcoholic HCl and treated with ether until turbidity. 2.1 g of 4-(3-chloro-4-methoxybenzylamino)-2-(3-hydroxypropylaminomethyl)-5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidine are obtained in the form of its dihydrochloride.

Provenance & Evidence