Trifluoroacetic acid → HCID 69355081, compound

Participants

Reaction Steps

The tert-butyl ester from stage A was deprotected with TFA in a similar manner to that described in Example 1. Purification was achieved by reverse phase HPLC on a Supelco ABZ plus column using a gradient of 45-50% acetonitrile/water as the eluent and analysis of the fractions by electrospray mass spectroscopy. The second eluting component was collected and confirmed by nOe studies to be the title compound, isolated as a solid. The first eluted component was the 4-α epimer (Example 56).

Provenance & Evidence