Potassium Hydroxide → HCID 9901202, compound

Participants

Reaction Steps

A solution of 4-methoxy-6-(5-methoxy-1-methyl-1H-indol-3-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine [361 mg, Reference Example 4] in methanol (20 mL) was treated with potassium hydroxide (1.53 g). The reaction mixture was stirred for 16 hours at room temperature and refluxed 1 hour. The solution was evaporated under reduced pressure and the residue partitioned between water and ethyl acetate. The organic phase was separated, then dried over magnesium sulfate and evaporated under reduced pressure. The residue was triturated with diethyl ether to give 4-methoxy-6-(5-methoxy-1-methyl-1H-indol-3-yl)-7H-pyrrolo[2,3-d]pyrimidine (155 mg) as a solid m.p.=184° C. MS: 309 [MH]+.

Provenance & Evidence