Bromotrimethylsilane → HCID 22179287, compound

HRID 854399Notes

Reaction equation

C[O:2][P:3]([CH2:7][NH:8][S:9]([C:12]1[S:13][CH:14]=[CH:15][CH:16]=1)(=[O:11])=[O:10])(=[O:6])[O:4]C.Br[Si](C)(C)C>>[S:13]1[CH:14]=[CH:15][CH:16]=[C:12]1[S:9]([NH:8][CH2:7][P:3](=[O:2])([OH:4])[OH:6])(=[O:10])=[O:11]

Participants

Reactant 2

HCID 76113Bromotrimethylsilane

HCID 22890942HCID 22890942, compound

Product 1

HCID 22179287HCID 22179287, compound

Procedure

The dimethyl ester (vii) was treated with bromotrimethylsilane according to the procedure described in Example 1, step 3, to afford the title compound: 1H NMR (300 MHz, CD3OD) δH 7.79 (dd, J=4.8, 1.2 Hz, 1H), 7.64 (dd, J=3.9, 1.2 Hz, 1H), 7.17 (dd, J=4.8, 3.9 Hz, 1H), 3.16 (d, J=13.2 Hz, 2H).

Sources & evidence

ORD record: ord-34835c1eff1a4acc9d62d32c478b92fa
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259172B2

Reaction notes

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