Sulfuric Acid → HCID 22320673, compound

HRID 854442Notes

Reaction equation

HRID 854442 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1.[S:26](=O)(=[O:29])([OH:28])[OH:27]>CC(C)=O>[C:3]1([CH3:9])[CH:4]=[CH:5][C:6]([S:26]([OH:29])(=[O:28])=[O:27])=[CH:7][CH:2]=1.[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]1[N:10]=[CH:11][O:12][C:13]=1[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([C:20]([CH:23]([CH3:25])[CH3:24])=[N:21][N:22]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 9949821CP-863187

Product 1

HCID 22320673HCID 22320673, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To 6-[4-(2,5-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine (5.0 g, 15 mmol) slurried in acetone (50 ml) was added sulfuric acid (850 μl). The resulting slurry was heated to reflux to form a solution and was then cooled and stirred at room temperature for 12 hours and filtered to yield 4.2 grams of 6-[4-(2,5-Difluoro-phenyl)-oxazol-5-yl]-3-isopropyl-[1,2,4]triazolo[4,3-a]pyridine p-toluenesulfonate.

Workup

  1. temperatureThe resulting slurry was heated
  2. temperatureto reflux
  3. customto form a solution
  4. temperaturewas then cooled
  5. filtrationfiltered

Sources & evidence

ORD record
ord-b786cab19b0b4e7c89720f45c2433095
Source dataset
uspto-grants-2007_08
Patent number
US07259171B2

Reaction notes

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