Imidazole → HCID 10336252, compound

HRID 854448Notes

Reaction equation

HRID 854448 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[NH:21]1[CH:25]=[CH:24][N:23]=[CH:22]1>>[N:21]1([C:2]2[N:7]=[C:6]([NH:8][C:9]3[CH:14]=[CH:13][C:12]([N:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[CH:11][CH:10]=3)[CH:5]=[N:4][CH:3]=2)[CH:25]=[CH:24][N:23]=[CH:22]1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 58934272HCID 58934272, compound

Product 1

HCID 10336252HCID 10336252, compoundYield 34%

Procedure

In a procedure analogous to example 2, reaction of 6-chloro-N-(4-morpholin-4-ylphenyl)pyrazin-2-amine (100 mg, 0.34 mmol) and imidazole (126 mg, 0.38 mmol) furnished the product (37 mg, 34%).

Sources & evidence

ORD record
ord-66e256fe7efc4599aa2ce3788eb3595d
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

Loading…