Imidazole → HCID 10038716, compound

HRID 854449Notes

Reaction equation

HRID 854449 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[CH:5]=[N:4][CH:3]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>>[F:16][C:13]1[CH:14]=[CH:15][C:10]([CH2:9][NH:8][C:6]2[CH:5]=[N:4][CH:3]=[C:2]([N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)[N:7]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 795ImidazoleHCID 40111420HCID 40111420, compound

Product 1

HCID 10038716HCID 10038716, compoundYield 77.2%

Procedure

In a procedure analogous to example 2, reaction of 6-chloro-N-(4-fluorobenzyl)pyrazin-2-amine (240 mg, 1.01 mmol) and imidazole (76 mg, 1.11 mmol) furnished the product (210 mg, 65%).

Sources & evidence

ORD record
ord-88608114a69d43b2ae77e1000c28d83f
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

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