Methoxyacetyl chloride → HCID 10431212, compound

HRID 854468Notes

Reaction equation

HRID 854468 reaction equation
[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[C:22]([NH2:25])[CH:23]=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[N:12][CH:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:26][O:27][CH2:28][C:29](Cl)=[O:30]>>[CH3:26][O:27][CH2:28][C:29]([NH:25][C:22]1[CH:23]=[CH:24][C:19]2[N:18]=[CH:17][N:16]([C:14]3[CH:13]=[N:12][CH:11]=[C:10]([NH:9][C@H:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH3:8])[N:15]=3)[C:20]=2[CH:21]=1)=[O:30]

Participants

3

Reactant 2

HCID 96623Methoxyacetyl chlorideHCID 10449319HCID 10449319, compound

Product 1

HCID 10431212HCID 10431212, compoundYield 25%

Procedure

In a procedure analogous to example 32, reaction of 1-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)-1H-benzimidazol-6-amine (33 mg, 0.10 mmol) and methoxyacetyl chloride (20 mg, 0.11 mmol) furnished the product (10 mg, 25%) after chromatography.

Sources & evidence

ORD record
ord-7d8095a967574f5d963a3c01beee0157
Source dataset
uspto-grants-2007_08
Patent number
US07259179B2

Reaction notes

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