Bromine → HCID 57431966, compound

HRID 854528Notes

Reaction equation

HRID 854528 reaction equation
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1)[CH3:2].[Br:15]Br>C(O)(=O)C>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([Br:15])[CH:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24408BromineHCID 13187337Ethyl 2-(4-hydroxyphenoxy)acetate

Product 1

HCID 57431966HCID 57431966, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a solution of (4-hydroxy-phenoxy)-acetic acid ethyl ester (0.59 g, 3 mmol) in acetic acid (1.5 mL) is added bromine (0.48 g, 9 mmol) in acetic acid (0.5 mL) at room temperature. After 5 min, solvent is evaporated and purified by column chromatography on silica gel giving the title compound (0.6 g).

Workup

  1. customsolvent is evaporated
  2. custompurified by column chromatography on silica gel giving the title compound (0.6 g)

Sources & evidence

ORD record
ord-2a9d2c831d33498f919559dc26087d5d
Source dataset
uspto-grants-2007_08
Patent number
US07259175B2

Reaction notes

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