反应详情

A mixture of 3-(4-Hydroxymethyl-2-methyl-phenyl)-propionic acid methyl ester (0.49 g, 2.35 mmol) and MnO2 (0.80 g, 9.20 mmol) in chloroform (5 mL) is stirred at RT for 4 days. The mixture is filtered through Celite; the Celite is washed with copious amounts of EtOAc. The filtrate is concentrated and purified by flash chromatography to yield the title compound (0.29 g, 60%).

1. filtrationThe mixture is filtered through Celite
2. washthe Celite is washed with copious amounts of EtOAc
3. concentrationThe filtrate is concentrated
4. custompurified by flash chromatography