Cesium carbonate → HCID 69471232, compound

Participants

Reaction Steps

To a solution of 5-chloromethyl-4-phenethyl-2-(4-trifluoromethyl-phenyl)-thiazole (190 mg, 0.5 mmol) and (4-Mercapto-2-methyl-phenoxy)-acetic acid ethyl ester (100 mg, 0.44 mmol) in acetonitrile (3 mL) is added Cs2CO3 (325 mg, 1 mmol). The mixture is stirred at room temperature over night, quenched by water, extracted with ethyl acetate, dried over sodium sulfate. Column chromatography on silica gel of the crude product gave 210 mg (83.5% yield) of the title compound.

Provenance & Evidence