Hydrochloric Acid → HCID 9959059, compound

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Reaction Steps

To a solution of {2-methyl-4-[4-phenethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethylsulfanyl]-phenoxy}-acetic acid ethyl ester (210 mg, 0.37 mmol) in THF (3 mL is added LiOH (1.0 M, 2 mL). After stirred at room temperature for 2 hrs, it is acidified with 5 N HCl, extracted with ether, dried over sodium sulfate. Concentration gave the title compound (200 mg). MS (ES): 544.2 (M++1); the structure is also confirmed by 1H NMR.

Provenance & Evidence