Cesium fluoride → HCID 10195159, compound

Participants

Reaction Conditions

Reaction Steps

{4-[4-Ethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-3-methyl-phenoxy}-acetic acid ethyl ester To a mixture of {3-Bromo-4-[4-ethyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-phenoxy}-acetic acid ethyl ester (100 mg, 0.18 mmol), methyl boronic acid (33 mg, 0.54 mmol) and cesium fluoride (90 mg, 0.54 mmol) in dioxane (2 mL) is added [1,1′]-(bisdiphenylphosphino)ferrocene]-dichloridepalladium (II) complex with methylene chloride (1:1, 29 mg) under nitrogen. The mixture is heated to 80° C. for 18 hrs, cooled to room temperature, loaded on silica gel column. Chromatography gave the title compound (80 mg).

Provenance & Evidence