HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 854565Generated: October 29, 2026
Hydrochloric Acid → 3-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid
https://huagongshe.com/reaction/854565
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester | HCID 69470791 | — |
| Product | 3-(2-Methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid | HCID 10238386 | 106.3% |
Reaction Steps
To a solution of 3-(2-methyl-4-{[5-methyl-2-(4-trifluoromethyl-phenyl)-oxazol-4-ylmethyl]-carbamoyl}-phenyl)-propionic acid ethyl ester (70 mg) in enthanol (1 mL) is added NaOH (5.0 N, 1.0 mL), the mixture is heated at 50° C. for 2 hrs, acidified with 5 N HCl, extracted with ethyl acetate, dried over sodium sulfate. Concentration gave the title compound (70 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07259175B2 |
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| Source dataset | uspto-grants-2007_08 |
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| ORD ID | ord-b596328195a8454288d945836f6419c8 |
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| Source note | uspto-grants-2007_08 |
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