反应详情

A solution of 3-(2-Methyl-4-{[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl]-amino}-phenyl)-propionic acid methyl ester (0.06 g, 0.13 mmol) and 5M NaOH (0.35 mL, 1.75 mmol) is heated to 70° C. for 14 h. Upon cooling, the solid is filtered and dried in vacuo to yield the title compound (10 mg, 17%) as the sodium salt. MS (ES): 435 (M+); the structure is also confirmed by 1H NMR.

1. temperatureUpon cooling
2. filtrationthe solid is filtered
3. customdried in vacuo