Ethanol → HCID 69141350, compound

HRID 854575Notes

Reaction equation

HRID 854575 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[CH:15][C:11]([C:12]([NH2:14])=[S:13])=[CH:10][N:9]=1.[CH3:17][O:18][C:19](=[O:26])[CH2:20][C:21](=O)[CH:22](Br)[CH3:23].[CH2:27](O)C>>[CH2:17]([O:18][C:19](=[O:26])[CH2:20][C:21]1[N:14]=[C:12]([C:11]2[CH:10]=[N:9][C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])=[CH:16][CH:15]=2)[S:13][C:22]=1[CH3:23])[CH3:27]

Participants

4

Reactant 3

HCID 702EthanolHCID 9815681Methyl 4-bromo-3-oxopentanoateHCID 86598135HCID 86598135, compound

Product 1

HCID 69141350HCID 69141350, compound

Procedure

A mixture of 6-(2-Fluoro-phenyl)-thionicotinamide (1.5 g, 6 mmol) and 4-Bromo-3-oxo-pentanoic acid methyl ester (1.51 g, 7.2 mmol) in ethanol (100 mL) is heated to reflux for 24 h, and concentrated. The residue is purified by column chromatography on silica gel yielding 1.7 g of the product.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 24 h
  3. concentrationconcentrated
  4. customThe residue is purified by column chromatography on silica gel yielding 1.7 g of the product

Sources & evidence

ORD record
ord-3c579136b4d045fcb8544484ec0e4d59
Source dataset
uspto-grants-2007_08
Patent number
US07259175B2

Reaction notes

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