反应详情

A solution of 1-benzyl-4-(4-fluoro-benzyl)-piperidin-4-ol (5.87 g, 19.6 mmol) in ethanol (80 ml) is treated with acetic acid (1 ml) and with 10% Pd on carbon (1 g). The mixture is stirred at RT under an atmosphere of hydrogen for 20 hours. The mixtre is filtered and the filtrate evaporated. The crude product is treated with dichloromethane. The resultant suspension is filtered and the white solid obtained is washed with cold dichloromethane to afford 4-(4-fluoro-benzyl)-piperidin-4-ol acetate [MH]+ 210.1

1. filtrationThe mixtre is filtered
2. customthe filtrate evaporated
3. additionThe crude product is treated with dichloromethane
4. filtrationThe resultant suspension is filtered
5. customthe white solid obtained
6. washis washed with cold dichloromethane