4-Methylbenzaldehyde → HCID 57434511, compound

HRID 854622Notes

Reaction equation

HRID 854622 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C1(C(=O)C(=NO)C)CCCCC1.C1(C)C=CC(C=O)=CC=1>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:15]=[CH:16][C:17]([CH3:20])=[CH:18][CH:19]=2)[O:6][C:7]=1[CH:8]1[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 77254-MethylbenzaldehydeHCID 6786725HCID 6786725, compoundHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 57434511HCID 57434511, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, 1-cyclohexyl-1,2-propanedione-2-oxime and p-tolu-aldehyde gave 4-iodomethyl-5-cyclohexyl-2-p-tolyloxazole.

Sources & evidence

ORD record
ord-86fabf25f2194613bf87fe4c6be212a7
Source dataset
uspto-grants-2007_08
Patent number
US07259177B2

Reaction notes

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