4-Methylbenzaldehyde → 2-(4-Methylphenyl)-4-iodomethyl-5-methyloxazole

HRID 854623Notes

Reaction equation

HRID 854623 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.C1(C)C=CC(C=O)=CC=1>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17]([CH3:20])=[CH:16][CH:15]=2)[O:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 77254-MethylbenzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 219803112-(4-Methylphenyl)-4-iodomethyl-5-methyloxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and p-tolualdehyde gave 4-iodomethyl-5-methyl-2-p-tolyloxazole.

Sources & evidence

ORD record
ord-5afcce69d7ef41deb79faca853bf5de9
Source dataset
uspto-grants-2007_08
Patent number
US07259177B2

Reaction notes

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