Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 854625Generated: October 25, 2026

3-(Trifluoromethyl)benzaldehyde → 2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazole

https://huagongshe.com/reaction/854625

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzaldehydeHCID 67990—
Reactant2,3-Butanedione monoximeHCID 6409633—
Reactant4-Iodomethyl-5-phenyl-2-p-tolyloxazoleHCID 57434504—
Product2-(3-Trifluoromethylphenyl)4-iodomethyl-5-methyloxazoleHCID 22493681—

Reaction Steps

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-trifluoromethylbenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethylphenyl)oxazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07259177B2
Source datasetuspto-grants-2007_08
ORD IDord-33682384b87843048a23f598c9061b4a
Source noteuspto-grants-2007_08