3-(Trifluoromethoxy)benzaldehyde → 4-(Iodomethyl)-5-methyl-2-[3-(trifluoromethoxy)phenyl]-1,3-oxazole

HRID 854630Notes

Reaction equation

HRID 854630 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1C=CC=CC=1.C/C(/C(C)=O)=N\O.[F:28][C:29]([F:40])([F:39])[O:30]C1C=C(C=CC=1)C=O>>[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:30][C:29]([F:40])([F:39])[F:28])[CH:15]=2)[O:6][C:7]=1[CH3:8]

Participants

4

Reactant 3

HCID 6051393-(Trifluoromethoxy)benzaldehydeHCID 64096332,3-Butanedione monoximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 224937064-(Iodomethyl)-5-methyl-2-[3-(trifluoromethoxy)phenyl]-1,3-oxazole

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, diacetylmonoxime and 3-trifluoromethoxybenzaldehyde gave 4-iodomethyl-5-methyl-2-(3-trifluoromethoxyphenyl)oxazole.

Sources & evidence

ORD record
ord-09d3c0affae5485ab3b14b2a2bac0b32
Source dataset
uspto-grants-2007_08
Patent number
US07259177B2

Reaction notes

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