3-(Trifluoromethyl)benzaldehyde → HCID 59701366, compound

HRID 854634Notes

Reaction equation

HRID 854634 reaction equation
[I:1][CH2:2][C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][C:17](C)=[CH:16][CH:15]=2)[O:6][C:7]=1[C:8]1[CH:13]=CC=CC=1.CC(=NO)C(=O)CC.[F:29][C:30]([F:40])([F:39])C1C=C(C=CC=1)C=O>>[CH2:8]([C:7]1[O:6][C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[C:18]([C:30]([F:40])([F:39])[F:29])[CH:19]=2)=[N:4][C:3]=1[CH2:2][I:1])[CH3:13]

Participants

4

Reactant 3

HCID 679903-(Trifluoromethyl)benzaldehydeHCID 67974532,3-Pentanedione, 2-oximeHCID 574345044-Iodomethyl-5-phenyl-2-p-tolyloxazole

Product 1

HCID 59701366HCID 59701366, compound

Procedure

Analogously to the building block synthesis of 4-iodomethyl-5-phenyl-2-p-tolyloxazole, pentane-2,3-dione-2-oxime and 3-trifluoromethyl-benzaldehyde gave 5-ethyl-4-iodomethyl-2-(3-trifluoromethylphenyl)-oxazole.

Sources & evidence

ORD record
ord-5d4d5ee6273e45f8ba9edfb142a868d5
Source dataset
uspto-grants-2007_08
Patent number
US07259177B2

Reaction notes

Loading…