Sodium hydride → Tert-butyl 2-[cis-3-(5-methyl-2-p-tolyloxazol-4-ylmethoxy)cyclohexylmethoxy]-2-methylpropionate

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Reaction Steps

200 mg of tert-butyl 2-(cis-3-hydroxycyclohexylmethoxy)-2-methyl-propionate are dissolved in 5 ml of dimethylformamide, and 20 mg of NaH (95%) are added. After 60 min of stirring at room temperature, 460 mg of 5-methyl-2-p-tolyloxazol-4-ylmethyl iodide in 1.5 ml of dimethylformamide are added at 0° C. The mixture is stirred at room temperature for 2 h. 10 ml of methyl tert-butyl ether and 10 ml of saturated NH4Cl solution are then added. The phases are separated, the aqueous phase is extracted once with methyl tert-butyl ether and the organic phases are dried over MgSO4 and concentrated. The residue is chromatographed on silica gel (heptane/ethyl acetate 5/1->1/1). 200 mg of the crude tert-butyl 2-[cis-3-(5-methyl-2-p-tolyloxazol-4-ylmethoxy)cyclohexylmethoxy]-2-methylpropionate are obtained as a yellow oil. C27H39NO5 (457), LCMS (ESI): 458 (MH+).

Provenance & Evidence