Hydrochloric Acid → HCID 69241635, compound

Participants

Reaction Steps

110 mg of ethyl 4-{cis-3-[2-(3-methoxyphenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyl}butyrate are dissolved in 5 ml of a mixture of tetrahydrofuran and water in a ratio of 2:1, and 20 mg of lithium hydroxide are added. The mixture is stirred at room temperature for 12 hours. The mixture is acidified by addition of 1 N HCl and extracted with ethyl acetate. The organic phase is dried over MgSO4, and the solvent is then removed under reduced pressure. The residue is purified by RP-HPLC. Freeze-drying gives 24 mg of 4-{cis-3-[2-(3-methoxyphenyl)-5-methyloxazol-4-ylmethoxy]cyclohexyl}butyric acid as a lyophilizate. C22H29NO5 (387.48), MS(ESI): 388 (M+H+).

Provenance & Evidence