反应详情

温度

120 °C

A suspension of 2.40 g (10 mmol) 4-chloromethyl-2-(4-methoxy-phenyl)-thiazole, 1.02 g (15 mmol) imidazole, 0.17 g (1 mmol) potassium iodide and 0.60 g (15 mmol) sodium hydroxide in 25 ml 2-methyl-2-butanol was stirred at 120° C. for 5 h. After evaporation, the residue was quenched with water and extracted with ethyl acetate. The extract was dried and concentrated to yield 2.47 g (91%) 1-[2-(4-methoxy-phenyl)-thiazol-4-ylmethyl]-imidazole as beige crystals, melting at 89-90° C.

1. customAfter evaporation
2. customthe residue was quenched with water
3. extractionextracted with ethyl acetate
4. customThe extract was dried
5. concentrationconcentrated