HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 854688Generated: October 26, 2026
Imidazole → 1-[2-(4-Methoxy-phenyl)-oxazol-4-ylmethyl]-imidazole
https://huagongshe.com/reaction/854688
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-oxazole | HCID 19958794 | — |
| Solvent | 2-Methyl-2-butanol | HCID 6405 | — |
| Product | 1-[2-(4-Methoxy-phenyl)-oxazol-4-ylmethyl]-imidazole | HCID 47281616 | 98.3% |
Reaction Steps
A suspension of 2.23 g (10 mmol) 4-chloromethyl-2-(4-methoxy-phenyl)-oxazole, 1.02 g (15 mmol) imidazole, 0.17 g (1 mmol) potassium iodide and 0.60 g (15 mmol) sodium hydroxide in 25 ml 2-methyl-2-butanol was stirred at 120° C. for 5 h. After evaporation, the residue was quenched with water and extracted with ethyl acetate. The extract was dried and concentrated to yield 2.51 g (98%) 1-[2-(4-methoxy-phenyl)-oxazol-4-ylmethyl]-imidazole as beige crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07259262B2 |
|---|
| Source dataset | uspto-grants-2007_08 |
|---|
| ORD ID | ord-5ee92ca5ddaa43feb9670e1304a63b2f |
|---|
| Source note | uspto-grants-2007_08 |
|---|
