Ammonia → 4-(4-Imidazol-1-ylmethyl-oxazol-2-yl)-phenol

Participants

Reaction Steps

A solution of 0.51 g (2.0 mmol) 1-[2-(4-methoxy-phenyl)-oxazol-4-ylmethyl]-imidazole in 15 ml 47% aqueous hydrobromic acid was stirred at 70° C. for 4 days. The reaction mixture was poured on ice, made basic with concentrated ammonia and extracted with ethyl acetate to yield 0.28 g (58%) raw 4-[4-(imidazol-1-ylmethyl)-oxazol-2-yl]-phenol as tan crystals.

Provenance & Evidence