反应详情

温度

25 °C

A solution of 2-(3,4-dichloro-phenyl)-3-[3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-propionic acid methyl ester (prepared as in Example 35, 1.03 g, 2.57 mmol) in methanol (6.4 mL) was treated with Amberlyst® 15 ion exchange resin (77 mg). The resulting reaction mixture was stirred at 25° C. for 16 h and then was heated at 45° C. for 1 h. The reaction mixture was allowed to cool to 25° C., and the resin was then filtered off and then washed well with ethyl acetate. The filtrate was concentrated in vacuo to afford 2-(3,4-dichloro-phenyl)-3-(3-hydroxy-cyclopentyl)-propionic acid methyl ester (807.7 mg, 99%) as a yellow oil which was used without further purification.

1. customThe resulting reaction mixture
2. temperaturewas heated at 45° C. for 1 h
3. temperatureto cool to 25° C.
4. filtrationthe resin was then filtered off
5. washwashed well with ethyl acetate
6. concentrationThe filtrate was concentrated in vacuo