Methanol → HCID 58934461, compound

Participants

Reaction Steps

The ester from Step 2 (4 g, 12 mmole) was dissolved in a mixture of THF:MeOH:H2O and LiOH.H2O (4 g, 95 mmole) was added and the mixture was stirred for 2 h at room temperature and then concentrated in vacuo. The mixture was acidified with 10% HCl and extracted with EtOAc. The EtOAc layer was washed twice with H2O, aqueous NH4Cl solution, dried over Na2SO4 concentrated in vacuo and to give 1.3 g (36% yield) of the product: 1H NMR (CDCl3/300 MHz) 7.48 (s, 1), 7.09 (s, 1H), 6.47 (s, 1H), 5.56 (q, 1H, J=6.9 Hz), 3.79 (s, 3H); ESHRMS m/z 307.0012 (M−H, C12H7ClF3O4, Calc'd 306.9985).

Provenance & Evidence