HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (2E)-4,4,4-trifluoro-2-butenoate → ethyl 7-isopropyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (2E)-4,4,4-trifluoro-2-butenoate | HCID 5371261 | — |
| Reactant | 4-Isopropyl salicylaldehyde | HCID 10149024 | — |
| Product | ethyl 7-isopropyl-2-(trifluoromethyl)-2H-chromene-3-carboxylate | HCID 69517862 | — |
Reaction Steps
This salicylaldehyde (Step 1) was condensed with Ethyl-4,4,4-triflurocrotonate via a similar method to that of Example 4a, Step 1 producing the ethyl ester (8.21 g, 84%) as yellow solid. This ester was of suitable purity to use without further purification: ESLRMS m/z 315 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259266B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-09b32436f2ea4b819efcedb1dfc9c4f0 |
| Source note | uspto-grants-2007_08 |