HCID 11360660, compound → HCID 58934987, compound

Participants

Reaction Steps

A racemic mixture of the compound prepared in Example 9k, Step 3 was chirally resolved using the same protocol as for Example 9d, Step 1 as peak 1 with retention time 4.27 min: ESHRMS m/z 367.0343 (M−H, C18H11ClF3O3, Calc'd 367.0329). 1HNMR (DMSO-d6/400 MHz) 13.34 (brs, 1H), 7.81 (s, 1H), 7.61 (s, 1H), 7.25-7.29 (m, 2H), 7.17-7.19 (m, 3H), 6.99 (s, 1H), 5.89 (q, 1H, J=7.1 Hz), 4.00 (s, 2H). [a]25589=−1.4 degrees (in MeOH).

Provenance & Evidence