HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → (4-Chloro-2-methylphenyl)(3-methoxyphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | m-Anisoyl chloride | HCID 74374 | — |
| Reactant | (4-Chloro-2-methylphenyl)boronic acid | HCID 5017600 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Product | (4-Chloro-2-methylphenyl)(3-methoxyphenyl)methanone | HCID 69518452 | — |
Reaction Steps
To a chilled stirred solution of 3-methoxybenzoyl chloride (5.0 g, 29.3 mmole) in acetone/water (3:1) was added 4-chloro-2-methylphenylboronic acid (5.0 g, 29.3 mmole) followed by PdCl2 (0.259 g, 5 mole %) and sodium carbonate (23.87 mL, 47 mmole). The solution was allowed to stir at room temperature overnight. The reaction workup and purification was conducted according to Example 9a, Step 1 producing the title compound (5.8 g, 76%). This ester was of suitable purity to use without further purification: ESLRMS m/z 261.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259266B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-8cdd4c0e871242d096ac7dc819170619 |
| Source note | uspto-grants-2007_08 |