1-Phenethylamine, (+)- → HCID 86599451, compound

Participants

Reaction Steps

(2R)-7-benzyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid from Example 91 (50 mg, 0.135 mmole) was dissolved into 1% Ethyl Acetate/Hexane (2 mL). (R)-(+)-α-methylbenzylamine (0.017 mL, 0.135 mmole) was added and the solution was allowed to stand at room temperature for 1 week until crystals appeared. Absolute configuration was determined by small molecule x-ray diffraction.

Provenance & Evidence