反应详情

A mixture of 3-benzoyl-2-methylphenyl acetate prepared as in Step 1 (6.85 g, 26.9 mmole) and KOH (15.0 g, 267 mmole) in H2O (100 mL) was stirred at room temperature for 18 h. The aqueous mixture was then washed with ethyl ether (3×200 mL), cooled to 0° C. and acidified with con. HCl. The resulting solid was filtered, washed with H2O and dried in vacuo to give 0.99 g (17% yield) of the product as an off-white crystalline solid: EIHRMS m/z 212.0829 (M+, C14H12O2, Calc'd 212.0837).

1. washThe aqueous mixture was then washed with ethyl ether (3×200 mL)
2. temperaturecooled to 0° C.
3. filtrationThe resulting solid was filtered
4. washwashed with H2O
5. customdried in vacuo