ethyl 8-but-1-ynyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate → ethyl 8-butyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Participants

Reaction Steps

A mixture of ethyl 8-but-1-ynyl-6-(trifluoromethoxy)-2-(trifluoromethyl)-2H-chromene-3-carboxylate prepared as in Example 21q, Step 1 (450 mg, 1.10 mmole) and 10% Pd/C (45 mg) in absolute ethanol was hydrogenated at 30 psi for 1.5 h. The catalyst was removed by filtration and the solvent was removed in vacuo to give 310 mg (68% yield) of the product as a yellow crystalline solid: EIHRMS m/z 412.1099 (M+, C18H18F6O4, Calc'd 412.1109).

Provenance & Evidence