ethyl 6-chloro-8-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate → ethyl 8-{[4-(aminosulfonyl)phenyl]ethynyl}-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Participants

Reaction Steps

Ethyl 6-chloro-8-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate prepared as in U.S. Pat. No. 6,271,253 B1 Example 73, Step 2 was reacted with 4-ethynylbenzene sulfonamide prepared as in Step 2 via a method similar to that described in Example 21f, Step 1 to give the product: ESHRMS m/z 503.0686 (M+NH4, C21H15ClF3O5SNH4, Calc'd 503.0655).

Provenance & Evidence