Chlorine → HCID 69517866, compound

HRID 854961Notes

Reaction equation

HRID 854961 reaction equation
[OH:1][CH2:2][C:3]([C:6]1[CH:15]=[C:14]2[C:9]([CH:10]=[C:11]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:12]([C:16]([F:19])([F:18])[F:17])[O:13]2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4].[Cl:25]Cl>CCOC(C)=O.C(Cl)Cl>[Cl:25][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][C:6]=1[C:3]([CH3:5])([CH3:4])[CH2:2][OH:1])[O:13][CH:12]([C:16]([F:18])([F:19])[F:17])[C:11]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:10]2

Participants

4

Reactant 2

HCID 24526ChlorineHCID 69516318HCID 69516318, compound

Product 1

HCID 69517866HCID 69517866, compound

Reagents, catalysts & solvents 1

HCID 21226138Dichloromethane ethylacetateSolvent

Procedure

A single treatment of ethyl 7-(2-hydroxy-1,1-dimethylethyl)-2-(trifluoromethyl)-2H-chromene-3-carboxylate (5.4 g 16 mmoles) with Cl2 was performed as described in Example 115 Step 2. Chromatography of the residue using a gradient of 0-10% EtOAc—DCM as eluent gave the title compound, 3.7 g, as a nearly colorless oil.

Sources & evidence

ORD record
ord-98a2aeff858943598fea3e25aa258be1
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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