2-(3-Methoxyphenyl)-2-methylpropanenitrile → 2-(3-Hydroxyphenyl)-2-methylpropanenitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of the title product of Example 106 Step 1 (520 mg, 2.97 mmoles) and pyridinium hydrochloride (2 g, 17.3 mmol) was stirred in an oil bath at 200-220 ° C. under a drying tube and so maintained for 3 h. After cooling, the mixture was partitioned between DCM and water, further extracted, and the combined organic extracts dried over Na2SO4, filtered, and evaporated to give the title compound, 416 mg, as a brownish oil.

Provenance & Evidence