Chlorine → HCID 69518201, compound

Participants

Reaction Steps

To a solution of ethyl 6-(trifluoromethyl)-6H-[1,3]dioxolo[4,5-g]chromene-7-carboxylate (500 mg, 1.58 mmoles) in 6 mL of TFA was added a solution of Cl2 6 mL, 0.28M) in TFA. After 30 min, another 6 mL of Cl2 solution was added and stirring continued. Zn dust (1.00 g, 15.3 mg-atm) was added, and stirred overnight. After concentration, the residue was chromatographed over silica gel using 20% EtOAc—hexane as eluent to give the title compound, 460 mg, as a yellow solid.

Provenance & Evidence