Chlorine → HCID 69519193, compound

Participants

Reaction Steps

Into a solution of the title product of Example 120 Step 4 (3.47 g, 7.83 mmoles) in 50 mL of HOAc was bubbled Cl2 gas. After 4 h, N2 gas was bubbled through, Zn dust (2.1 g, 32.1 mg-atm) was added, and the mixture stirred for 1 h. The mixture was concentrated, and the residue chromatographed over silica gel using 10% MeOH—DCM as eluent to give the title compound, 3.61 g, as a white foam.

Provenance & Evidence