Chlorine → HCID 69517632, compound

HRID 854970Notes

Reaction equation

[N:1]1([C:7]2[CH:16]=[C:15]3[C:10]([CH:11]=[C:12]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:13]([C:17]([F:20])([F:19])[F:18])[O:14]3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:26]Cl>>[Cl:26][C:8]1[CH:9]=[C:10]2[C:15](=[CH:16][C:7]=1[N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[O:14][CH:13]([C:17]([F:19])([F:20])[F:18])[C:12]([C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:11]2

Participants

Reactant 2

HCID 24526Chlorine

HCID 69516473HCID 69516473, compound

Product 1

HCID 69517632HCID 69517632, compound

Procedure

The ester of Example 143 Step 1 (0.38 g, 1.06 mmol) was treated with Cl2 following the method of Example 103 Step 3 to give ethyl 6-chloro-7-piperidin-1-yl-2-(trifluoromethyl)-2H-chromene-3-carboxylate (0.16 g, 0.41 mmol). The product structure was consistent with 1H, 19F and 13C NMR analyses.

Sources & evidence

ORD record: ord-132c58d97903443099da5c74a5238cf0
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07259266B2

Reaction notes

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