5-Bromo-3-chloro-2-hydroxybenzaldehyde → ethyl 6-bromo-8-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate

HRID 854987Notes

Reaction equation

HRID 854987 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([Cl:11])[C:5]([OH:10])=[C:6]([CH:9]=1)[CH:7]=O.ClC1C=C(I)C=C2C=1O[CH:20]([C:23]([F:26])([F:25])[F:24])[C:19]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=C2>>[Br:1][C:2]1[CH:9]=[C:6]2[C:5](=[C:4]([Cl:11])[CH:3]=1)[O:10][CH:20]([C:23]([F:24])([F:26])[F:25])[C:19]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:7]2

Participants

3

Reactant 2

HCID 27166965-Bromo-3-chloro-2-hydroxybenzaldehydeHCID 58934641ethyl 8-chloro-6-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Product 1

HCID 58935022ethyl 6-bromo-8-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Procedure

The ethyl 6-bromo-8-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylate was prepared from 5-bromo-3-chloro-2-hydroxybenzaldehyde in an analogous manner to step 2, preparation of ethyl 8-chloro-6-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate.

Sources & evidence

ORD record
ord-f868e8f7521e4c4e99a6e1314597b920
Source dataset
uspto-grants-2007_08
Patent number
US07259266B2

Reaction notes

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