HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethynyl-4-fluorobenzene → HCID 69518018, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethynyl-4-fluorobenzene | HCID 522627 | — |
| Reactant | ethyl 6-chloro-8-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate | HCID 21883552 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 69518018 | HCID 69518018 | — |
Reaction Steps
To 0.350 g (0.809 mmole) of ethyl-6-chloro-8-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate was added 47 mg (0.040 mmole) tetrakis(triphenylphosphine)palladium(0), 15 mg (0.081 mmole) copper (I) iodide, 5mL degassed toluene, 0.338 mL (2.43 mmole) degassed TEA, and 0.139 mL (1.21 mmole)1-ethynyl-4-fluorobenzene. The mixture was stirred overnight at room temperature. The mixture was concd and the resulting oil was purified using reverse phase chromatography to afford a crystalline solid. MS (ES+) 425 (M+1, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07259266B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-edd9018a8d2943828fc791b7735fbb26 |
| Source note | uspto-grants-2007_08 |